My doctoral research (1994-1999) looked at how 2 different drugs (rapamycin and wortmannin, used as immunosuppressors) affected the way that a type of cancer cells “feed” and get nutrients from their environment when the cells were given a “feeding signal” via a growth factor (TGF-β1). By understanding how each drug works, we could look at the potential for either drug to have a role in dissecting the signaling pathways in cancer cells, and look for “rational” drug targets.
Biochemical Studies of Rapamycin and Wortmannin on TGF-b1-Mediated G1-S Cell Cycle Profession